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Watch Closely (two)pentobarbital will reduce the level or effect of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Robust CYP3A4 inducers may reduce suvorexant efficacy; if enhanced suvorexant dose necessary, don't exceed 20 mg/working dayAfter stopping a CYP3A4 inducer, since the effects on the inducer de